Urolithin A Studies
Urolithin A is a naturally occurring compound that has gained scientific interest for its role in cellular energy and mitochondrial health.
Research into Urolithin A is ongoing. Much of the current understanding comes from laboratory studies and clinical trials exploring its relationship to mitochondrial function and muscle health.
What Is Urolithin A?
Urolithin A is produced when certain compounds found in foods like pomegranate are metabolised by specific gut bacteria.
However, research suggests that many adults may not naturally produce meaningful amounts. Supplementation provides a direct and consistent source of Urolithin A.
4 studies, same result
Significant improvements in muscle strength (~12 %), improved aerobic endurance and physical performance... (Read more on PubMed)
After 8 weeks UA supplementation, improvements in muscle strength & endurance metrics; decreased oxidative stress & inflammation... (Read more on PubMed)
Safe and well tolerated. Showed improvements in muscle endurance (hand & leg muscles) and mitochondrial health biomarkers... (Read more on PubMed)
Urolithin A in muscle health and performance encompass its regulatory effects on promoting muscle protein synthesis while inhibiting degradation, potential enhancement of endurance, fatigue resistance and anti-inflammatory properties. (Read more on PubMed)
Can you make Urolithin A?
In the study, only 12% of participants had detectable levels of Urolithin A at baseline. After drinking pomegranate juice, about 40% were able to produce meaningful amounts - but this depended on whether their gut microbiome contained the right bacteria. The majority (60%) either produced very little or none at all, showing that diet alone cannot guarantee effective levels.
6x more Urolithin A with supplements
A clinical study showed that to reach the same level of Urolithin A as one supplement capsule (500 mg), people would need to drink about 1.5 liters of pomegranate juice – the richest natural source. Yet, only around 40% of people can efficiently transform pomegranate compounds into Urolithin A. In contrast, direct supplementation delivered over 6 times higher and consistent Urolithin A levels in everyone.
Mitochondria and Cellular Energy
Mitochondria are structures within cells that help generate energy.
Scientific interest in Urolithin A centres around its potential role in supporting mitochondrial function. Studies have explored how it may influence processes related to cellular maintenance and energy production.
Maintaining healthy mitochondrial function is associated with:
- Energy production
- Muscle function
- Cellular resilience
- Healthy aging processes
Research in Muscle Health
Human clinical studies have examined Urolithin A in relation to muscle health in aging adults.
In certain studies, supplementation has been associated with markers related to muscle function and cellular energy pathways. Research in this area continues to evolve.
It is important to note that results can vary between individuals.
Healthy Aging Research
Interest in Urolithin A has grown within the field of healthy aging research.
Scientists are exploring how mitochondrial function influences long-term vitality and physical performance as people age.
Urolithin A is being studied for its role in supporting these natural biological processes.
A Growing Area of Science
While research is promising, Urolithin A remains an area of emerging science. Ongoing clinical studies aim to further understand its mechanisms and long-term effects.
As with all dietary supplements, individual responses may differ.
Important Information
This content is provided for educational purposes only and is not intended as medical advice.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Always consult a qualified healthcare professional before starting any new supplement.