The short answer
Both Urolithin A and CoQ10 play valuable roles in supporting mitochondrial health. While CoQ10 helps mitochondria produce energy, Urolithin A helps renew and clean out damaged mitochondria through a process called mitophagy. When used together, they may support overall energy, vitality, and healthy aging more effectively than either alone.
Understanding Mitochondrial Support
Mitochondria are often described as the “powerhouses” of our cells. They convert food into energy that powers everything from muscle contractions to brain function. Over time, mitochondria can become damaged or less efficient, which is why many people look to supplements that help maintain or optimize their function.
What CoQ10 Does
Coenzyme Q10 (CoQ10) is a naturally occurring compound in the body that supports cellular energy production. It acts as a cofactor in the electron transport chain, a vital step in the process that turns nutrients into ATP - the main energy currency of cells.
As we age, CoQ10 levels may decline, and some individuals choose to supplement to maintain healthy energy levels, exercise performance, or cardiovascular health.
What Urolithin A Does
Urolithin A works differently. It helps the body remove old and dysfunctional mitochondria through mitophagy, allowing new, healthy ones to take their place. This process supports cellular renewal and energy efficiency.
Unlike CoQ10, which fuels existing mitochondria, Urolithin A helps the body maintain a cleaner, more efficient mitochondrial network.
Urolithin A and CoQ10 - A Complementary Duo
Rather than choosing one or the other, some people find that combining Urolithin A with CoQ10 supports both mitochondrial energy production and renewal. One works to clean up old mitochondria, while the other keeps the energy engines running smoothly.
This complementary approach appeals to biohackers, athletes, and those interested in longevity who want to take a comprehensive approach to cellular health.
Other Supplements That Support Mitochondrial Function
For a complete mitochondrial support stack, some individuals also explore (more in this article):
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PQQ (Pyrroloquinoline Quinone) – linked to mitochondrial biogenesis (creating new mitochondria)
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L-Carnitine – supports energy transport into mitochondria
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Alpha Lipoic Acid (ALA) – antioxidant that supports mitochondrial function
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Magnesium – essential for ATP production
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NAD+ precursors (like NMN or NR) – support cellular energy metabolism
Final Thoughts
Mitochondrial health is a foundation of energy, performance, and longevity. While CoQ10 helps existing mitochondria perform better, Urolithin A supports their renewal and long-term function. Together, they may provide a balanced approach to supporting vitality from the cellular level.
Learn more about our Urolithin A supplement and how it can support your daily energy and performance.
